It could be due to the graphics card. Mastercam does not support onboard graphics cards like intel. Most of the time when the start up gets hung up it is due to that reason. One thing that you can try to see if it is graphics related is to go to the start menu and under the Mastercam folder select "Advanced Configurations". Then got to "Graphics Support" and disable "Hardware Acceleration" then try to open Mastercam, if it opens then it has something to do with the graphics card.